A Lot of Icing But Little Cake? Taking Integrated Reporting Forward

Sustainability and Quality: Icing on the Cake

In the literature several definitions of sustainability and software sustainability can be found. However, we think none of them can be applied to the software development context. For that reason, in this poster we cook some existing definitions and we will propose a new one specific for the software development. From this definition we try to create a new recipe, discovering how to combine su...

Spending a little to save a lot

Phase III studies of disease-modifying agents for neurodegenerative disorders generally require hun­ dreds of patients to be followed for at least 2 years at a cost of millions of dollars. No matter how promis­ ing an agent may appear in preclinical studies and animal models, preliminary evidence that the treat­ ment is likely to be helpful in patients (proof-of­ concept) and that it is reasona...

Give a little ... get a lot.

Protease-activated receptors and EDHF: the icing on the cake?

The regulation of vascular smooth muscle cell tone by the vascular endothelium was initially described by Furchgott and Zawadzki, suggesting the existence of an endothelium-derived relaxing factor (EDRF) acting through cGMP, which was later identified as nitric oxide (NO) (see reference [1] for review). Since then, other actions of NO such as control of cell growth, blood cell–endothelial cell ...

Taking a LITTLE WORK Along

The continuing micro-miniaturization of components has moved high-powered, microprocessor-based machines from the desktop, to the laptop, to notebook-sized, and now to palmtop computers. These machines are distinguished in their hardware technology, but supporting software has not kept pace: the predominant operating system on such machines is MS-DOS, absent integrated support for distributed c...